Abstract: The special diet and drink ’Chinese wolfberry-mulberry-raspberry decoction’, which is a combination of traditional food and Chinese medicine, is a treasure of Chinese dietotherapy and health preservation culture. Its ingredients, mulberry, wolfberry and raspberry, have a variety of physiological activities, such as lowering blood fat, blood sugar and curing kidney disease, and have potential preventive and therapeutic effects on diabetes and kidney disease. In this study, network pharmacology, molecular docking and antioxidant test were used to study the molecular mechanism of medicated diet ’Chinese wolfberry-mulberry-raspberry decoction’ in the treatment of diabetes nephropathy. TCMSP database was used to collect the active ingredients and action targets of ’Chinese wolfberry-mulberry-raspberry decoction’, and the targets related to diabetes nephropathy were obtained from GeneCards, OMIM, TTD and DisGeNET databases. Taking the intersection targets of active ingredient in ’Chinese wolfberry-mulberry-raspberry decoction’and the disease, the interaction network of ’Chinese wolfberry-mulberry-raspberry decoction active ingredient-disease target’was constructed by using STRING database and Cytoscape 3.8.0. Based on the interaction network, the gene ontology（GO） and Kyoto Encyclopedia of Genes（KEGG） pathways enrichment analysis of the intersection targets were performed using the DAVID database, and the MCODE and CytoHubba in Cytoscape 3.8.0 were used to screen key targets. Molecular docking were performed using AutoDock Vina program to evaluate the binding ability and action mode between key targets and active ingredients. Based on the analysis of co-targets and core clusters of diabetes nephropathy and ’Chinese wolfberry-mulberry-raspberry decoction’, β-sitosterol, daidzein, morin, quercetin β-carotene and ellagic acid were screened as the active components, and IL6, IL1B, PPARG, MMP9 and VEGFA as the core action targets. Molecular docking results showed that both the main active components and the targets had high binding energy The results of the eliminate ability tests of ’Chinese wolfberry-mulberry-raspberry decoction’extract to 1,1-diphenyl-2-picrylhydrazyl（DPPH） radical, hydroxyl radical and 2,2’-azino-bis（3-ethylbenzthiazoline-6-sulfonic acid）（ABTS） radical cation showed that ’Chinese wolfberry-mulberry-raspberry decoction’had high antioxidant capacity and could play a protective role in nephrotic diabetes. This study preliminarily revealed the mechanism of action and antioxidant mechanism of ’Chinese wolfberry-mulberry-raspberry decoction’in the collaborative treatment of diabetes nephropathy in the mode of ’multi-component multi target multi pathway’, which provides a theoretical basis for the industrial application of traditional medicinal diet ’Chinese wolfberry-mulberry-raspberry decoction’.